Depending on how long you use testosterone replacement therapy and which dose you’re taking, your sperm count could completely zero out. Without GnRH, the body doesn’t produce its own testosterone-nor does it produce more sperm. When you take exogenous testosterone in the form of medication, this process is disrupted if brain never detects a low level of testosterone, so it doesn’t produce more GnRH.
In turn, the pituitary gland secretes follicle stimulating hormone (FSH) and luteinizing hormone (LH), signalling sperm and testosterone production in the testes. To simplify, the brain constantly monitors the body’s level of testosterone and produces gonadotropin-releasing hormone (GnRH) when it detects that levels are low. The male body naturally produces testosterone through a complex process of hormone interactions. How Does Testosterone Therapy Make You Sterile? But if you’re concerned about your fertility, you need to seriously consider the risks of TRT before taking any medications that supplement testosterone. But some men never recover their sperm count after treatment.įor hypogonadal men who do not plan to have biological children in the future, TRT may be the best path to addressing the symptoms of low testosterone. For most individuals, this infertility is only temporary and their sperm count rises to normal levels when treatment is discontinued. Some men even reach a sperm count of zero while on testosterone. While a lower sperm count doesn’t necessarily cause infertility, the lower it goes, the more difficult it will be for you and your partner to conceive. Most men experience a significant decrease in sperm count when taking TRT-which is why testosterone is being studied as a form of male birth control. And if you’re planning to father children in the future, TRT might seriously inhibit your ability to do so.ĭoes testosterone therapy make you sterile? In some cases, yes. Importantly, if you’re already struggling with infertility, this treatment could make things worse. With these benefits, it’s no surprise that between 20, androgen prescriptions increased fourfold.īut while TRT does have incredible benefits for men who experience symptoms caused by low testosterone, it’s not right for every man. Widely recognized as the best treatment for low testosterone, TRT can significantly improve mood, energy, and libido, helping you feel like yourself again. doi:10.1016/j.repbio.2019.07.Testosterone replacement therapy (TRT) can be life-changing. Diet and sperm quality: nutrients, foods and dietary patterns. Salas-Huetos A, James ER, Aston KI, Jenkins TG, Carrell DT. Laboratory and clinical management of leukocytospermia and hematospermia: a review. Khodamoradi K, Kuchakulla M, Narasimman M, et al. Chronic prostatitis and its detrimental impact on sperm parameters: a systematic review and meta-analysis. doi:10.3238/arztebl.2017.0186Ĭondorelli RA, Russo GI, Calagero AE, Morgia G, La Vignera S. Hematospermia-a symptom with many possible causes. Mathers MJ, Degener S, Sperling H, Roth S. Some of the factors involved in male infertility: a prospective review. Semen analysis and sperm function tests: How much to test? Indian J Urol. The effects of cigarette smoking on male fertility. Metabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma. Relationship between semen production and medical comorbidity. Treasure Island, FL StatPearls Publishing 2022.Įisenberg ML, Li S, Behr B, Pera RR, Cullen MR. Leslie SW, Siref LE, Soon-Sutton TL, Khan MAB. Is there a close relation between sperm count and ejaculation volume? J Reprod Contracep.
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